Eugenol mitigated acute lung but not spermatic toxicity of C60 fullerene emulsion in mice
نویسندگان
چکیده
C60 fullerene (C60) is a nano-pollutant that can damage the respiratory system. Eugenol exhibits significant anti-inflammatory and antioxidant properties. We aimed to investigate time course of emulsion-induced pulmonary spermatic harms, as well effect eugenol on emulsion toxicity. The first group mice (protocol 1) received intratracheally (1.0 mg/kg BW) or vehicle were tested at 12, 24, 72 96 h (F groups) thereafter. second 2) vehicle, 1 later gavaged with (150 mg/kg) experiments done 24 after instillation. Lung mechanics, morphology, redox markers, cytokines epididymal spermatozoa analyzed. Protocol 1: Tissue damping (G) elastance (H) significantly higher in F24 than others groups, except for H F72. Morphological inflammatory parameters worst subsequently declined until h, whereas worsened over whole period. eliminated increase G, H, cellularity, cytokines, attenuated oxidative stress induced by exposure, but had no sperm. Hence, exposure deteriorated lung morphofunctional, characteristics increased risk infertility. Furthermore, avoided those changes, did not prevent sperm damage.
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ژورنال
عنوان ژورنال: Environmental Pollution
سال: 2021
ISSN: ['1873-6424', '0269-7491']
DOI: https://doi.org/10.1016/j.envpol.2020.116188